• The project, funded by CORFO, is led by Dr. Claudia Ortiz, researcher at the Faculty of Chemistry and Biology, and it focuses on developing a biological filter using brown algae, enhancing copper and arsenic recovery from the water used in the mining process. The filters can also be used as desalination agents. This involves the real possibility of using seawater as an alternative to mining production processes.

Water consumption in Chile’s mining industry is now a multi-faceted problem. Water shortage in large deposits of minerals located in the center and northern part of the country, the disadvantages of the systems available for water treatment, and the figures, show that 95 percent of the recourse that enters the plants ends up as waste.

Given this reality, the project led by Dr. Claudia Ortiz, researcher at the Faculty of Chemistry and Biology, aims to obtain a biofilter prototype (biological filters) based on Chilean brown algae, which are chemically modified for the absorption of large concentrations of elements such as copper and arsenic.

In words of the researcher, "the direct recovery of copper, by using biofilters, will cause productive benefit and also an increase in the life cycle of the water process, resulting in more efficient resource usage. Also, the content of elements, such as arsenic and copper, will decrease. Their presence in the environment is a global problem because of the persistence, bioaccumulation and toxicity to living organisms. "

This project corresponds to one of the six initiatives of the Applied R & D project funded by CORFO, which the University will run.

Because of its high efficiency at low concentrations of heavy metals and its low cost, the filters may also be used as desalination agents and this means the real possibility of using seawater, as an alternative to mining production processes.

"The project involves a comprehensive solution, which is efficient and cheap to industry. Currently, this field faces three problems: access to water resources, optimization of copper production, by recovering this metal from the waste, and the use of sea water in the process," Dr. Ortiz says. She adds that in a first phase, the project includes the development of laboratory-scale biofilter prototype and then the project scaling to industrial level.

The project is conducted by: the Department of Biology of the Faculty of Chemistry and Biology; the Department of Geographic Engineering of the Faculty of Engineering, and the Department of Mechanical Engineering, as hydro-specialized support, as well as Good Harbour Technologies a Canadian company specialized in process scaling, and División Codelco Chuquicamata, as associated with the project.

• Dr. Claudio Vasquez investigates the resistance of microorganisms in the Antarctic to tellurite, a derivative of metallic tellurium, which is very harmful and toxic to the environment.

Tellurium is a very scarce element in the earth's crust and its biological role is unknown to date. Although in its elemental state (Te ° metallic tellurium) it exhibits no toxicity, some of its derivatives, such as tellurite, are highly damaging to most bacteria.

In this context, Dr. Claudio Vasquez, professor at the Faculty of Chemistry and Biology at the U. of Santiago will be in charge of the Fondecyt project: "Antarctic tellurite-resistant bacteria: new mechanisms of resistance",  for three years.

The academic works with bacteria isolated in Antarctica, in order to analyze how the microorganisms react in a cold context in contact with the toxic. For the research, 800 toxic- resistant microorganisms, coming from 100 different Antarctic samples, were isolated. "Of all the samples, we chose four which showed greater resistance to unveil the defense mechanisms they use," the researcher says.

Dr. Vasquez adds that "over the years, we have identified proteins that help the cell to remove this toxic and, therefore, we think that these bacteria that have received more stress by being in extreme conditions at the Antarctic, could exhibit more sophisticated mechanisms. Our goal is to find new genes that encode novel proteins involved in the defense against these toxics.” the expert says.

As a projection of this study, the introduction of new genes into plants that grow in tellurium- contaminated environments, such as some mining areas, is expected. This would help the plants so that they can eliminate the polluting elements.

Pollution

The tellurite, produced as a result of industrial pollution, drains in groundwater by inhibiting or eliminating microorganisms that might be beneficial. It affects bacteria, fungi, plants and animals. For this reason, it is important to control the discharges which come from industrial exudates containing tellurium.

Tellurium is the molecular basis of solar cells that collect energy; therefore, any accident that might happen with these solar panels could release toxic elements.

• Dr. Alonso Arellano, academic at the Department of Metallurgical Engineering, conducts a Dicyt research which seeks patterns that allow the projection of a possible earthquake or volcanic eruption of great magnitude, through the analysis of high-resolution satellite images.

Predicting an earthquake is one of the highest aspirations of the researchers in this field worldwide. In a country like Chile, which is considered highly seismic, this search has become an essential need. In this context, a new process for early detection of earthquakes arises: the analysis of high resolution satellite images.

Dr. Alonso Arellano conducts a project funded by the Department of Scientific and Technological Research (Dicyt) in this field of research. He felt motivated in 2004 while he was doing a Ph.D. at the State University of Russia and subsequently investigated related phenomena, such as the case of the Popocatepetl volcano, located in the south of Mexico.
Through his project, called "Use of high-resolution satellite images for the study of strong earthquakes and related phenomena", additional information is sought to identify more patterns and better statistics.

Based on this information, associated phenomena could be addressed, through the analysis of high resolution satellite images for earthquake precursors. "To achieve this, images are analyzed before, during and after the earthquake. Then, each image is scanned in order to find typical structures, veins, fractures, faults, and thus confirm existing or new patterns,”  Arellano said.

According to this researcher, the study is based, on the assumption that the stress of the Earth’s crust can be seen in the form of lines. "The lines are visible when processing high resolution images captured by satellites, although they develop over 30 kilometers deep. For this reason, these images have become an important tool to detect areas of potential earthquakes,” he remarks.

Although in the last decade many similar investigations have been carried out by the international group led by Dr. Arellano in Chile, and by Dr. Dimitar Ouzounov in the United States, this study will differ in two aspects:  first, the use of the Chilean satellite FASAT Charlie, if the agreement with the Air Force, through the Aerophotogrametric Service, becomes effective. The second aspect is the use of software for the study of images, developed at the University of Santiago, Adelgeo.

Dr. Arellano’s collaborators are Ph.D. students in Engineering Science (Automatic and Process specializations) and the Master’s degree in Geomatics. As noted by professor Arellano, "they play an important role, because their motivation to do new things nourishes the investigation."

By Lorena Jimenez

• Inspired by the Fukushima nuclear disaster, academics from the U. of Santiago are developing a model, based on a mathematical theory that defines in minutes an action plan to deal with disasters. They published a paper about this research in the indexed journal "International Journal of Computers, Communications & Control."

It has been two years since the earthquake in Japan happened. This catastrophe caused more than 15,000 deaths and the most important nuclear disaster of the 21st century: the Fukushima Nuclear Plant explosion. This disaster demonstrated the great amount of time required to determine an action plan to cope with these events and the consequent risk for human lives.

This kind of situations led researchers from our University to find a model that could improve these response times. The project manager is Oscar Vasquez, industrial engineer graduated in this University; he has a Master’s degree, from the Ecole Polytechnique in Paris, and currently he is a  Ph.D. candidate at the Université Pierre et Marie Curie, Paris VI. He works with Dr. Juan Sepúlveda, director of the Department of Industrial Engineering, and the academics Miguel Alfaro and Luis Valenzuela-Osorio. Together, they published a paper about this research in the indexed journal "International Journal of Computers, Communications & Control."

The title of the paper written by the research team, composed of industrial and electrical engineers, was "Disaster response project planning: a resolution method based on a theoretical model of games.” The research was published in April by the specialized journal.

Vasquez says the method is a good and fast solution to the problem of assigning activities among a number of available resources in disaster environments. Based on the mathematical theory of “game", they seek to deal with computer applications that are currently used to solve these situations. This is achieved by finding the balance point as part of a theoretical game where activities and resources are the players.

The researcher adds: "Getting a good answer just in seconds is a key issue in disaster situations, considering that the computational complexity of the problem might involve obtaining the optimal solution in hours or even days, a period of time in which the increasing disaster might cause the loss of human lives and infrastructure."

The results of the proposed model showed a difference of 15 percent in relation to the optimal solution, but less than 1 percent in relation to the time required by last generation software. "The idea behind this kind of environment is to save as many lives as possible, and this is achieved if  less time is used in order to give a good answer to the problem”, the specialist says.

Currently, the team is improving the resolution method, defining new subroutines and starting players. Preliminary results have shown a reduction of the gap between their results and the optimal solution, with a difference of only 9 percent.

By Lorena Jimenez
 

• In the Southern Hemisphere, Chile is the largest exporter of berries. Therefore, national researchers focus their efforts on increasing their life, to allow these products to reach more distant markets. An eco active container which aims to contribute to this purpose has been generated at U. Santiago.

In 2008, Dr. Maria Paula Junqueira, academic at the Technological Faculty, committed herself  to making a contribution to the food area, and she was part of  the task of converting Chile into a food power. Thus, through a Fondef project, she tried to combat the limitations generated, particularly by the fungus Botrytis cinerea, in the so -called  berries, and this allowed their  extension of life.

The closing of the investigation "Life extension of fresh berries by using eco-active packaging” was held on Friday 19^th at the Plaza San Francisco Hotel, where the results were presented to the participating institutions.

The eco active container has an antifungal agent in his film, which fights the fungus specifically mentioned. Also, it  is also friendly with the environment, because it is recyclable. To verify the efficiency of the invention, tests with raspberries and blueberries were tested in Chile, while in England raspberries and blackberries were used, because we are in different seasons.

Of all the berries used in the study, raspberries showed a better response to interact with the packaging, and this helped to extend its life in two days.

"We had a very promising result," the academic at the Department of Science and Food Technology remarked; she  added that "due to the final results of this research, an  initiative was taken in order to try with other fruits like grapes and strawberries and we already have companies which are interested in participating. "

Dr. Junqueira thanked the cooperation of the school, saying that she had "an unconditional support from the University from the start and then at all stages involved in  the project."

This work, which also involved Dr. Maria Angelica Bargains and Dr. Francisco Rodriguez, members of the same academic unit, gave birth to a patent application in Chile, which will also be replicated abroad soon.

Companies’ experience

In the presentation of results, representatives of the participating companies  were present. Enrique Harvgreaves attended in representation of  Typack company, a packaging  company. He said: "I do hope that this product is on the market soon.” He also thanked the opportunity to develop a collaborative work with the University.

Meanwhile, Alvaro Acevedo, from Vitalberry, referred to the contribution generated in the production process of these fruits during the investigation. "The market demands have pushed us to the improvement of production processes, and this has increased the quality requirements demanded for these products," he said. He also emphasized that this result "has a lot of potential; undoubtedly, it is a product to be applied massively".

Dr. Luis Magne, Head of Technology Transfer, attended on behalf of the Vice-President for Research, Development and Innovation. He said "we take on the challenge of leading the University on the path of innovation. The road has not been easy but  maturity has been achieved in the sense of understanding what technological research is. "

Luisa Martínez, financial analyst of the Fund for the Promotion of Science and Technology was also present in this event.

 By Valeria Osorio

• The project, led by Dr. Ricardo Salazar, professor at the Faculty of Chemistry and Biology of the University, aims at decontaminating the water from dyes waste and additives, by using electricity and solar energy.

The textile industry in Chile was born in the mid-nineteenth century and expanded thanks to the measures of protection of the internal market which were implemented at that time. Another factor was the arrival of Palestinian immigrants that gave prosperity to the development of the industry.

However, as all industrial activity, this industry was also a contaminant, due to the use of water in its tasks.

This situation becomes a serious problem when you consider that our country has  supply and drought problems. In this context, Dr. Ricardo Salazar, an academic at the Faculty of Chemistry and Biology at the U. Santiago, is leading the Fondecyt project: "Degradation of dyes in wastewater from the textile industry by electrochemical oxidation technologies.” With this project, he aims to provide a solution for wastewater reuse in this process.

The study comes from a previous work by this expert that consisted in analyzing water decontamination of pesticides used in the wine industry. "The first two projects involved water treatment in the laboratory and comprised a chemical study. Now, however, I proposed the construction of a pilot plant to treat more wastewater from the textile industry”, Salazar said.

The project aims to be a contribution to environmental conflict resolution. This is the vital motivation for this academic, who seeks to decontaminate waters that contain dyes wastes and additives. To achieve this, he will work with electricity and solar energy and without using chemicals.

In addition, Dr. Salazar adds that "laws are becoming more stringent for industries in terms of technology demand and waste disposal rates. Therefore, the industries will have to be prepared. The idea is to step forward and provide an approach to this conflict and be useful in the future. "

Purification Process

The purification process is performed by the hydroxyl radical, which derives from water oxidation. This element reacts with the organic components present in the water, degrades pollutants and transforms the contaminant organic compounds into carbon dioxide.

Some of the steps included in this four-year project are: to finish the work in the laboratory, which aims to observe what happens in the whole process; identify each of the compounds that are produced and, finally, build a pilot plant. In this last stage, the scholar has the direct support of Dr. Julio Romero, project co-investigator who is also a researcher at the Faculty of Engineering of the University.

For Dr. Salazar, the importance of the research that he develops lies, mainly, on the human capital formation and in the "responsibility of changing the image of research in the country. Our work could contribute to the enterprise, the industry and, obviously, the University, as we could get the latest technological equipment to develop the project and internationalize the name of the institution. "

By Marcela González

• His paper deals with details about how a person's exposure to carbon dioxide affects cerebral blood flow. The information was provided by experimental British patients, as part of a collaborative work with the University of Leicester.

Dr. Max Chacón, professor at the Department of Informatics Engineering, Faculty of Engineering, was awarded the 2011 Jack Perkins Prize by the Institute of Physics and Engineering in Medicine (IPEM) of England, for his publication "Non-linear multivariate modelling Hemodynamics of cerebral hemodynamics with Autoregressive Support Vector Machines.”

 The award, which consists of  £ 250, is given annually to the best paper published during the year in the Medical Engineering & Physics journal, after a review carried out by a specialized committee that evaluates aspects such as the novelty and impact of the research.

 Dr. Chacon thanked the award and noted that this type of survey research confirms the good work being done in this University. "This is an important recognition for us, especially because our paper in the area of cerebral self regulation did not belong to the field of biomechanics, the journal’s strongest line of research, which could have been  the most possible winner”, he said.

The winner added that "all the profits for this recognition are indirect: for example, increasing the bonds of cooperation not only with the university we work with (Leicester), but also with other foreign institutions".

Significant contribution to medicine

The awarded paper is part of a specific area called cerebral hemodynamics. Professor Chacón  is working with two other researchers: Claudio Araya, former student of Master’s degree at the U. of Santiago, and Ronney Panerai from the University of Leicester (England).

 The cerebral hemodynamics acquires vital importance, because the estimates of international organizations involved in the field of health in Chile indicate that by 2025 more people will die from brain strokes than heart attacks. It is believed that the blood flow would be strongly linked to vascular accidents and also with a number of diseases, such as Alzheimer's, arteriosclerosis (carotid artery, mainly), head trauma, vascular dementia and diabetes, among others.

"Cerebral strokes are rising very strongly in the country and the causes are unknown. One thing that causes brain damage is the stronger flow in the arteries. It is known that the brain has a flow control system, and this means that, although the pressure varies in the body, the flow is almost constant in the brain. If there is little flow, one loses consciousness and, conversely, if there is a lot of flow an artery breakdown happens, “Chacón explained.

This mechanism, which constantly generates blood flow into the brain, is what researchers try to model through a data–based nonlinear system. This publication addresses one of the topics related to cerebral hemodynamics, because of the data given by the English researcher who provided the information based on 16 healthy patients who breathe in air with a small fraction (5%) of carbon dioxide (CO2) through a mask. The aim was to know how breathing in this gas affects the regulation of the blood flow in the brain.

"We proved that it is possible to represent changes in the inhalation of CO2 in a person by using this nonlinear model and this has metabolic implications, for instance. We know that breathing in a fraction of CO2 produces changes, which are equivalent to those experienced by people with diabetes, i.e. a metabolic problem, and these problems affect the blood flow in the same way as CO2 does it, “the researcher said.

Prize

The IPEM is an institution dedicated to joining professionals from the physical sciences, clinical engineering, the academic world, the health services and the industry, in order to share knowledge and advances in science and technology. Since 2000, it gives the Jack Perkins Prize in honor of his first journal’s editor, who died in 2000.

• The increase in cardiovascular diseases and the lack of reliable information, on the mechanical capacity of the arteries, became the engine of a promising research led by Claudio Garcia, professor  in the Department of Mechanical Engineering.
• "Normally, engineers work with steel, concrete, industrial materials, and leave aside those materials with unknown behaviors," the expert says. He claims that his study of the aorta artery can become a tool for "predicting dangerous states in patients. We want to help physicians in taking decisions when performing an operation," he says.

According to the World Health Organization (WHO), the leading cause of death in the world is related to cardiovascular diseases. These pathologies do not distinguish gender and they affect mostly people in poor or developing countries.

In this context, he estimates that about 23.6 million people will die in 2030, due to cardiovascular complications; that is why the study led by Dr. Claudio Garcia –professor in the Department of Mechanical Engineering of the University of Santiago- is very relevant. He seeks to quantify the effects of the diseases and the age in the arteries, particularly the aorta, one of the main arteries of the human body.

This year, he presented part of his findings in an ISI publication, entitled "Mechanical Behaviour and rupture of normal and pathological human ascending aortic wall," which appeared in June in the Medical & Biological Engineering & Computing journal.

He explains that arterial mechanics defines the structural and functional capacity of the arteries, and it can be studied to obtain new information about their behavior and how the mechanical properties affect the diseases or the patients’ age.

"Our idea was to identify and assess the properties of the materials that make up this blood vessel and try to differentiate how it is affected by age or various diseases. We wanted to know how these factors alter the properties of the material that constitute the aorta,” Dr. Garcia says. He began this research in his doctoral thesis, a study about the properties of biomaterial at the Polytechnic University of Madrid, an organization that has provided resources for his research, which also has the support of a FONDECYT grant.

According to this professional, his interest in finding out about this health subject arose during his stay in the European country, where he felt motivated "by the permanent interaction with physicians who wanted to understand how the diseases affect this kind of biological materials. In their view, having an index to predict rupture states is important because, most of the time, the criteria used by doctors are only the arteries size or diameter. "

"Normally, engineers work with steel, concrete, industrial materials, and leave aside those materials with unknown behaviors." Research to establish and study how they behave is just starting," the expert says. Then, he refers to one of the main conclusions of his study, which released the mechanical properties of materials that were unknown. He points out that the main difference among patients is the age. As people become older, the arteries become less elastic and the mechanical resistance drops significantly, so they are more prone to rupture.

The importance of this information is to "predict dangerous states in patients. We want to help physicians in taking decisions when performing an operation," he says.

• In this way, Dr. Rodolfo Madrid, from the Faculty of Chemistry and Biology, refers to the Conicyt  funds granted for implementing a research ring that will join top scientists. The challenge is to study the physiological role of the TRP ion channels involved in detecting thermal and pain stimuli, among many other physiological processes. Knowing how these channels work may allow the development of treatments for attacking diseases related to the their malfunction.

Three research groups and a common commitment -understanding the role of TRP channels in heat sensitivity, pain and synaptic plasticity-  define the project led by Dr. Rodolfo Madrid researcher at the Faculty of Chemistry and Biology. His initiative has recently received funds from the "2011 Fourth Contest of Research Rings in Science and Technology" organized by the National Commission for Scientific and Technological Research, CONICYT. (See related article).

"Study of the Physiological role of TRP Channels in Thermotransduction and Synaptic Plasticity" is an associative research project that joins three research groups: two correspond to the University’s laboratory of neurosciences at the Faculty of Chemistry and Biology -one led by Dr. Rodolfo Madrid and the other by Dr. Bernardo Morales-  the third is the Interdisciplinary Center for Neuroscience from Valparaiso, led by Dr. Patricio Orio. The joint challenge is to study the physiological role of various members of a group of membrane proteins: polymodal ion channels of the TRP (Transient Receptor Potential) superfamily in diverse physiological processes. For this purpose, they will have the annual funds of 150 million pesos, for three years.

"We want to study the role of various TRP channels in the electrical response of thermoreceptors of cold and nociceptors against various physiological and pathophysiological situations, in order to develop a mathematical model that could serve as a tool for predicting the electrical behavior of these neurons against modifications -that could be the result, for example, of an inflammatory process or an injury-  and  determining  the role of ion channels in regulating neuronal communication in particular regions of the central nervous system," Dr. Rodolfo Madrid explains.

"TRP channels are part of a large group of proteins involved in the detection of thermal stimuli and nociception, among many other physiological processes, and have recently been associated with learning and memory processes," the specialist says.
 

Advanced human capital

This associative research, will attract and train new high-level human capital. It will also  incorporate doctoral and postdoctoral students and, in this way, the group of neuroscientists at the University’s Faculty of Chemistry and Biology will become stronger.

"Besides, we will work with the collaboration of laboratories that belong to some of the world's best centers in the field, such as the Institute of Neuroscience in Alicante, Cambridge University and John Hopkins University, worldwide reference points in the study of neuroscience. This will not only help the growth and consolidation of  our group, but it will also allow our students go directly to stay in those centers,” the researcher says.

Besides, Dr. Madrid values ​​the grant of this ring project "as a recognition that should extend not only to the members of our group, but to all the neuroscientists at the University. From our point of view, this is the most important project of neuroscience that our institution has received and it means that our work has not been the result of improvisation, " he finally  points out.

• For the second consecutive year, our  University was positioned in the third place of the largest national patent requests prepared by the National Industrial Property Institute (INAPI,  in Spanish). Dr. Louis Magne,  director of the Department of Technology Management, attended the awards ceremony  and he highlighted the efforts of the University to generate technological innovations.

Our University has managed to gradually increase the protection of intellectual property of the technologies  generated through its research and development. In 2011 it presented a total of 28 requests  at national and  international levels and through the Cooperation Treaty about Patenting Matters (PCT, in Spanish).

The number of nine national patent records required in 2011, helped to put the University in third place, according to the "INAPI Report 2012". The leader of this ranking was Universidad de  Concepción and P. Pontificia Universidad Católica, with a total number of thirteen requests for inventions each.

The award ceremony for this important achievement was held last Thursday in the new premises of INAPI and was chaired by Tomás Flores the Vice Secretary of Economics, and Maximiliano Santa Cruz, INAPI director.  Dr. Louis Magne, director of the Department of Technology Management from the office of Research and Development attended the ceremony and  represented our University. He  noted that patenting is a priority for the institution.

"The University has an important increase of the research that has  potential for new businesses, and this has allowed  the  identification of the results that might get a patent and which are the basis of innovative technologies that could be transferred to the productive sector," he said.

Throughout its history, the  Universidad de Santiago de Chile has presented 63 requests  for national patents. At the international level, it has presented 50 requests  in various countries, mostly in the United States. Of the total applications, 28 patents have been given, eleven  in Chilean territory, three in the U.S. and the rest in other countries.

"We are currently working to achieve that these patents generate licenses and then royalties, meeting  the challenge that Chile has about becoming a generator of technology," Magne explained.

What is the meaning of patenting?

A patent is an exclusive right granted by the State for the protection of an invention, so it recognizes and guarantees the exclusive commercial exploitation for the holder of the invention, thus preventing others from appropriating the benefits involved in its exploitation.

Obtaining these patents in the University is paramount as it demonstrates the ability to generate appropriable knowledge, and states the basis of technological products that have a future to contribute to the country and become  part of  the national and international markets.

To achieve this, the Technology Management Department is responsible for encouraging researchers to conduct applied research projects whose results are evaluated in its appropriability and evaluated for their further development, until the patent is generated.

The patents that are requested belong to the University, with the recognition of the authorship  for the inventors. If the invention is commercialized, 50 percent is for the group of researchers that  generates the patent and the remaining 50 percent for the University.